Table 7d. Characteristics of Miscellaneous Drugs
Last Updated: December 20, 2023
- The information in this table is derived from data on the use of these drugs for FDA-approved indications or in investigational trials. It is supplemented with data on the use of these drugs in patients with COVID-19 or MIS-C, when available.
- For dose modifications for patients with organ failure or those who require extracorporeal devices, please refer to product labels, when available.
- There are currently not enough data to determine whether certain medications can be safely coadministered with therapies for the treatment of COVID-19. When using concomitant medications with similar toxicity profiles, consider performing additional safety monitoring.
- The potential additive, antagonistic, or synergistic effects and the safety of using certain combination therapies for the treatment of COVID-19 are unknown. Clinicians are encouraged to report AEs to the FDA MedWatch program.
- For drug-drug interaction information, please refer to product labels and visit the Liverpool COVID-19 Drug Interactions website.
|Drug-Drug Interaction Potential
Not recommended by the Panel for the treatment of COVID-19 in nonhospitalized patients.
Doses for COVID-19 in Clinical Trials
Primarily used for the treatment of MIS-C. Currently under investigation in clinical trials.
|Dose for MIS-C
There is insufficient evidence for the Panel to recommend either for or against the use of metformin in nonhospitalized patients. Not recommended by the Panel for the treatment of COVID-19 in hospitalized patients, except in a clinical trial.
|Doses for COVID-19 in Clinical Trials
Key: AE = adverse event; CYP = cytochrome P450; FDA = Food and Drug Administration; IBW = ideal body weight; IV = intravenous; IVIG = intravenous immunoglobulin; MAOI = monoamine oxidase inhibitor; MIS-C = multisystem inflammatory syndrome in children; OCT = organic cation transporter; the Panel = the COVID-19 Treatment Guidelines Panel; PO = oral; TRALI = transfusion-related acute lung injury