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Immunomodulators Under Evaluation for the Treatment of COVID-19

Last Updated: November 3, 2020

Summary Recommendations
Summary Recommendations

Dexamethasone and Other Corticosteroids

Other Immunomodulators

There are insufficient data for the Panel to recommend either for or against the use of the following immunomodulators for the treatment of COVID-19:

  • Interleukin (IL)-1 inhibitors (e.g., anakinra).
  • Interferon beta for the treatment of early (i.e., <7 days from symptom onset) mild and moderate COVID-19.

The Panel recommends against the use of the following immunomodulators for the treatment of COVID-19, except in a clinical trial:

  • Anti-IL-6 receptor monoclonal antibodies (e.g., sarilumab, tocilizumab) or anti-IL-6 monoclonal antibody (siltuximab) (BI).
  • Interferons (alfa or beta) for the treatment of severely or critically ill patients with COVID-19 (AIII).
  • Bruton’s tyrosine kinase inhibitors (e.g., acalabrutinib, ibrutinib, zanubrutinib) and Janus kinase inhibitors (e.g., baricitinib, ruxolitinib, tofacitinib) (AIII).
Rating of Recommendations: A = Strong; B = Moderate; C = Optional
Rating of Evidence: I = One or more randomized trials with clinical outcomes and/or validated laboratory endpoints; II = One or more well-designed, nonrandomized trials or observational cohort studies; III = Expert opinion