Table 4e. Characteristics of Antiviral Agents, Including Antibody Products
Last Updated: July 21, 2023
- This table contains drugs and products that have shown antiviral activity against SARS-CoV-2, including small-molecule antiviral drugs, CCP, and IFNs.
- RDV and RTV-boosted nirmatrelvir (Paxlovid) are approved by the FDA for the treatment of COVID-19. RTV-boosted nirmatrelvir is currently only available from supplies obtained under the EUA, and its use must be consistent with the EUA terms and conditions.
- MOV and CCP have received EUAs from the FDA for the treatment of COVID-19.
- For drug-drug interaction information, please refer to product labels, EUA fact sheets, and Drug-Drug Interactions Between Ritonavir-Boosted Nirmatrelvir (Paxlovid) and Concomitant Medications.
- For the Panel’s recommendations on using the drugs listed in this table, refer to Antiviral Agents, Including Antibody Products; Therapeutic Management of Nonhospitalized Adults With COVID-19; Therapeutic Management of Hospitalized Adults With COVID-19; Therapeutic Management of Nonhospitalized Children With COVID-19; Therapeutic Management of Hospitalized Children With COVID-19; and Pregnancy, Lactation, and COVID-19 Therapeutics.
Drug Name | Dosing Regimens | Adverse Events | Monitoring Parameters | Drug-Drug Interaction Potential | Comments |
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Anti-SARS-CoV-2 Antiviral Drugs (Small-Molecule Antivirals) | |||||
Ritonavir-Boosted Nirmatrelvir (Paxlovid) Approved by the FDA for use in adults and authorized under an FDA EUA for use in children (aged ≥12 years and weighing ≥40 kg) for the treatment of mild to moderate COVID-19 in high-risk individuals. | FDA Prescribing Information/EUA Dose for COVID-191,2 eGFR ≥60 mL/min
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Remdesivir Approved by the FDA for the treatment of COVID-19 in individuals aged ≥28 days and weighing ≥3 kg. | Dose for Adults and Children Weighing ≥40 kg
Dose for Children Aged ≥28 Days and Weighing 3 kg to <40 kg
Total Treatment Duration
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Molnupiravir Authorized under an FDA EUA for the treatment of mild to moderate COVID-19 in high-risk individuals aged ≥18 years. | Dose Recommended in FDA EUA
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COVID-19 Convalescent Plasma | |||||
High-Titer COVID-19 Convalescent Plasma Authorized under an FDA EUA for the treatment of COVID-19 in patients who are immunocompromised or who are receiving immunosuppressive treatment. | Dose Recommended in FDA EUA
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Interferons | |||||
IFN Beta Not approved by the FDA and not recommended by the Panel for the treatment of COVID-19. Currently under investigation in clinical trials. |
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PEG-IFN Lambda Not approved by the FDA and not recommended by the Panel for the treatment of COVID-19. | Dose for COVID-19 in Clinical Trials
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Key: AE = adverse event; ALT = alanine transaminase; AST = aspartate aminotransferase; CBC = complete blood count; CCP = COVID-19 convalescent plasma; CHF = congestive heart failure; CYP = cytochrome P450; eGFR = estimated glomerular filtration rate; EUA = Emergency Use Authorization; FDA = Food and Drug Administration; HSR = hypersensitivity reaction; IFN = interferon; IV = intravenous; MATE = multidrug and toxin extrusion protein; MOV = molnupiravir; NG = nasogastric; OATP = organic anion transporting polypeptide; OG = orogastric; OTC = over-the-counter; the Panel = the COVID-19 Treatment Guidelines Panel; P-gp = P-glycoprotein; PEG-IFN = pegylated interferon; PO = oral; RDV = remdesivir; RTV = ritonavir; SUBQ = subcutaneous; TACO = transfusion-associated circulatory overload; TRALI = transfusion-related acute lung injury; ULN = upper limit of normal |
References
- Ritonavir-boosed nirmatrelvir (Paxlovid) [package insert]. Food and Drug Administration. 2023. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/217188s000lbl.pdf.
- Food and Drug Administration. Fact sheet for healthcare providers: Emergency Use Authorization for Paxlovid. 2023. Available at: https://www.fda.gov/media/155050/download.
- BC COVID Therapeutics Committee COVID Therapy Review and Advisory Working Group. Therapeutic brief: crushing nirmatrelvir/ritonavir (Paxlovid). 2022. Available at: http://www.bccdc.ca/Health-Professionals-Site/Documents/COVID-treatment/Crushing_Paxlovid.pdf.
- Remdesivir (Veklury) [package insert]. Food and Drug Administration. 2023. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/214787s019lbl.pdf.
- Food and Drug Administration. Fact sheet for healthcare providers: Emergency Use Authorization for Lagevrio (molnupiravir) capsules. 2023. Available at: https://www.fda.gov/media/155054/download.
- Food and Drug Administration. Fact sheet for health care providers: Emergency Use Authorization (EUA) of COVID-19 convalescent plasma for treatment of coronavirus disease 2019 (COVID-19). 2021. Available at: https://www.fda.gov/media/141478/download.