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This page is being revised. For updated information, please see the Panel’s statements on prioritizing patients for outpatient therapies, using available therapies in high-risk outpatients, and evaluating Paxlovid drug-drug interactions.

Table 2f. Characteristics of Antiviral Agents

Last Updated: December 16, 2021

  • RDV is the only antiviral drug that is approved by the FDA for the treatment of COVID-19. Some medications that are currently being evaluated in clinical trials for the treatment of COVID-19 are also included in this table. The inclusion of these drugs does not imply that the Panel approves of their use.
  • Information on CQ, HCQ, and LPV/RTV are available in the archived versions of the Guidelines. The Panel recommends against using these agents to treat COVID-19.
  • There are limited or no data on dose modifications for patients with organ failure or those who require extracorporeal devices. Please refer to product labels, when available.
  • There are currently not enough data to determine whether certain medications can be safely coadministered with therapies for the treatment of COVID-19. When using concomitant medications with similar toxicity profiles, consider performing additional safety monitoring.
  • The potential additive, antagonistic, or synergistic effects and the safety of using combination therapies for the treatment of COVID-19 are unknown. Clinicians are encouraged to report AEs to the FDA MedWatch program.
  • For drug interaction information, please refer to product labels and visit the Liverpool COVID-19 Drug Interactions website.
  • For the Panel’s recommendations on using the drugs listed in this table, please refer to the individual drug sections or Therapeutic Management of Hospitalized Adults With COVID-19.
Table 2f. Characteristics of Antiviral Agents
Table 2f. Characteristics of Antiviral Agents

References

  1. Remdesivir (Veklury) [package insert]. Food and Drug Administration. 2020. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/214787Orig1s000lbl.pdf.
  2. Ivermectin (Stromectol) [package insert]. Food and Drug Administration. 2009. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/050742s024s025lbl.pdf.
  3. Nitazoxanide (Alinia) [package insert]. Food and Drug Administration. 2017. Available at: https://www.alinia.com/wp-content/uploads/2017/08/prescribing-information.pdf.