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Table A. SARS-CoV-2 Variants and Susceptibility to Anti-SARS-CoV-2 Monoclonal Antibodies

Last Updated: August 18, 2022

Table A. SARS-CoV-2 Variants and Susceptibility to Anti-SARS-CoV-2 Monoclonal Antibodies

Table A. SARS-CoV-2 Variants and Susceptibility to Anti-SARS-CoV-2 Monoclonal Antibodies
Years of CirculationWHO Label and Pango LineageNotable MutationsBEBTIX Plus CILBAM Plus ETECAS Plus IMDSOT
In Vitro SusceptibilityaAnticipated Clinical ActivityIn Vitro SusceptibilityaAnticipated Clinical ActivityIn Vitro SusceptibilityaAnticipated Clinical ActivityIn Vitro SusceptibilityaAnticipated Clinical ActivityIn Vitro SusceptibilityaAnticipated Clinical Activity
Variants Currently or Recently Circulating in the United States
2021–presentOmicron BA.2T376A, K417N, N440K, E484A, Q493R, N501YNo changeActiveNo changeActiveMarked reductionUnlikely to be activeMarked reductionUnlikely to be activeMarked reductionUnlikely to be active
2022–presentOmicron BA.4BA.2 plus del69/70, L452R, F486V, Q493 reversionNo changeActiveModerate reductionbActivecMarked reductionUnlikely to be activeMarked reductionUnlikely to be activeMarked reductionUnlikely to be active
2022–presentOmicron BA.5BA.2 plus del69/70, L452R, F486V, Q493 reversionNo changeActiveModerate reductionbActivecMarked reductionUnlikely to be activeMarked reductionUnlikely to be activeMarked reductionUnlikely to be active
Variants That Are Not Currently Circulating in the United States
2020–2021Alpha B.1.1.7N501YNo changeActiveNo changeActiveNo changeActiveNo changeActiveNo changeActive
2020–2021Beta B.1.351K417N, E484K, N501YNo changeActiveNo changeActiveMarked reductionUnlikely to be activeNo changedActiveNo changeActive
2020–2021Gamma P.1K417T, E484K, N501YNo changeActiveNo changeActiveMarked reductionUnlikely to be activeNo changedActiveNo changeActive
2020–2021Delta B.1.617.2, non-AY.1/AY.2L452R, T478KNo changeActiveNo changeActiveNo changeActiveNo changeActiveNo changeActive
2021–2022Omicron B.1.1.529/ BA.1K417N, N440K, G446S, E484A, Q493R, N501YNo changeActiveModerate reductionbActivecMarked reductionUnlikely to be activeMarked reductionUnlikely to be activeNo changeActive
2021–2022Omicron BA.1.1BA.1 plus R346KNo changeActiveModerate reductionbActivecMarked reductionUnlikely to be activeMarked reductionUnlikely to be activeNo changeActive

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