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Table A. SARS-CoV-2 Variants and Susceptibility to Anti-SARS-CoV-2 Monoclonal Antibodies

Last Updated: April 29, 2022

Table A. SARS-CoV-2 Variants and Susceptibility to Anti-SARS-CoV-2 Monoclonal Antibodies

Table A. SARS-CoV-2 Variants and Susceptibility to Anti-SARS-CoV-2 Monoclonal Antibodies
WHO LabelPango LineageCDC Variant ClassNotable MutationsBAM Plus ETECAS Plus IMDBEBSOTTIX Plus CIL
In Vitro SusceptibilityaAnticipated Clinical ActivityIn Vitro SusceptibilityaAnticipated Clinical Activity In Vitro SusceptibilityaAnticipated Clinical ActivityIn Vitro SusceptibilityaAnticipated Clinical ActivityIn Vitro SusceptibilityaAnticipated Clinical Activity
AlphaB.1.1.7VBMN501YNo changeActiveNo changeActiveNo changeActiveNo changeActiveNo changeActive
BetaB.1.351VBMK417N, E484K, N501YMarked reductionUnlikely to be activeNo changebActiveNo changeActiveNo changeActiveNo changeActive
GammaP.1VBMK417T, E484K, N501YMarked reductionUnlikely to be activeNo changebActiveNo changeActiveNo changeActiveNo changeActive
DeltaB.1.617.2, non-AY.1/ AY.2VOCL452R, T478KNo changeActiveNo changeActiveNo changeActiveNo changeActiveNo changeActive
OmicronB.1.1.529/ BA.1VOCK417N, N440K, G446S, E484A, Q493R, N501YMarked reductionUnlikely to be activeMarked reductionUnlikely to be activeNo changeActiveNo changeActiveModerate reductioncActived
OmicronB.1.1.529/ BA.1.1VOCR346K, K417N, N440K, G446S, E484A, Q493R, N501YMarked reductionUnlikely to be activeMarked reductionUnlikely to be activeNo changeActiveNo changeActiveModerate reductioncActived
OmicronB.1.1.529/ BA.2VOCT376A, K417N, N440K, E484A, Q493R, N501YMarked reductionUnlikely to be activeMarked reductionUnlikely to be activeNo changeActiveMarked reductionUnlikely to be activeNo changeActive