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Anti-SARS-CoV-2 Monoclonal Antibodies

Last Updated: December 16, 2021

Table A. SARS-CoV-2 Variants and Susceptibility to Anti-SARS-CoV-2 Monoclonal Antibodies
WHO LabelPango LineageCDC Variant ClassNotable MutationsBAM Plus ETECAS Plus IMDSOT
In Vitro SusceptibilityaAnticipated clinical activityIn Vitro SusceptibilityaAnticipated clinical activityIn Vitro SusceptibilityaAnticipated clinical activity
AlphaB.1.1.7VBMN501YNo changeActiveNo changeActiveNo changeActive
BetaB.1.351VBMK417N, E484K, N501YMarked reductionUnlikely to be activeNo changebActiveNo changeActive
GammaP.1VBMK417T, E484K, N501YMarked reductionUnlikely to be activeNo changebActiveNo changeActive
DeltaB.1.617.2, non-AY.1/AY.2VOCL452R, T478KNo changeActiveNo changeActiveNo changeActive
OmicronB.1.1.529VOCK417N, N440K, G446S, E484A, Q493R, N501YAnticipated marked reductionUnlikely to be activeAnticipated marked reductionUnlikely to be activeAnticipated no change24Active