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Table 2a. Therapeutic Management of Nonhospitalized Adults With COVID-19

Last Updated: December 28, 2022

Table 2a. Therapeutic Management of Nonhospitalized Adults With Mild to Moderate COVID-19 Who Do Not Require Supplemental Oxygen
Patient DispositionPanel’s Recommendations
All Patients
  • All patients should be offered symptom management (AIII).
  • The Panel recommends against the use of dexamethasonea or other systemic corticosteroids in the absence of another indication (AIIb).
Patients Who Are at High Risk of Progressing to Severe COVID-19bPreferred therapies. Listed in order of preference:
  • Ritonavir-boosted nirmatrelvir (Paxlovid)c,d (AIIa)
  • Remdesivird,e (BIIa)
Alternative therapy. For use when the preferred therapies are not available, feasible to use, or clinically appropriate:
  • Molnupiravird,f,g (CIIa)
Each recommendation in the Guidelines receives 2 ratings that reflect the strength of the recommendation and the quality of the evidence that supports it. See Guidelines Development for more information.