Table 3b. Characteristics of Immune-Based Therapy Under Evaluation for the Treatment of COVID-19
Last Updated: August 27, 2020
- The information in this table is derived from data on the use of these drugs and biologic products for FDA-approved indications or from investigational trials; it is supplemented with data from patients with COVID-19 where available.
- The effective dosing of these agents for the treatment of COVID-19 is unknown. Therefore, the doses listed below are primarily derived from FDA-approved indications or from clinical trials investigating therapies for COVID-19.
- There are limited or no data on dose modifications for patients with organ failure or those who require extracorporeal devices. Please refer to product labels, when available.
- Treatment-related AEs associated with immune-based therapy in patients with COVID-19 are not well defined. Whether the frequency and severity of AEs associated with use of these agents for FDA approved-indications are the same in patients with COVID-19, especially in critically ill patients, is unknown. AEs associated with long-term use of these drugs (i.e., months to years) are not included in this table because treatment for COVID-19 is not long term. Please refer to product labels, when available.
- There are currently not enough data to determine whether certain medications can be safely coadministered with therapies for the treatment of COVID-19. When using concomitant medications with similar toxicity profiles, consider additional safety monitoring.
- The potential additive, antagonistic, or synergistic effects and the safety of combination therapies for the treatment of COVID-19 are unknown. Clinicians are encouraged to report AEs to the FDA MedWatch program.
- For drug interaction information, please refer to product labeling and visit the Liverpool COVID-19 Drug Interactions website.
- For information on drugs that prolong the QTc interval, please visit CredibleMeds.org.
Table 3b. Characteristics of Immune-Based Therapy Under Evaluation for Treatment of COVID-19
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