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Table 3a. Immune-Based Therapy Under Evaluation for the Treatment of COVID-19: Clinical Data to Date

Last Updated: August 27, 2020

Information presented in this table may include data from preprint/non-peer reviewed articles. This table will be updated as new information becomes available.

Table 3a. Immune-Based Therapy Under Evaluation for Treatment of COVID-19: Clinical Data to Date
Table 3a. Immune-Based Therapy Under Evaluation for Treatment of COVID-19: Clinical Data to Date


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  3. Joyner MJ, Wright RS, Fairweather D, et al. Early safety indicators of COVID-19 convalescent plasma in 5,000 patients. J Clin Invest. 2020. Available at:
  4. Liu STH, Lin H, Baine I, et al. Convalescent plasma treatment of severe COVID-19: a matched control study. medRxiv. 2020;Preprint. Available at:
  5. Salazar E, Perez KK, Ashraf M, et al. Treatment of COVID-19 patients with convalescent plasma in Houston, Texas. medRxiv. 2020;Preprint. Available at:
  6. Ahn JY, Sohn Y, Lee SH, et al. Use of convalescent plasma therapy in two COVID-19 patients with acute respiratory distress syndrome in Korea. J Korean Med Sci. 2020;35(14):e149. Available at:
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  28. Peginterferon alfa-2a (PEGASYS) [package insert]. Food and Drug Administration. 2017.
  29. Zhou Q, Chen V, Shannon CP, et al. Interferon-alpha2b Treatment for COVID-19. Front Immunol. 2020;11:1061. Available at:
  30. Synairgen announces positive results from trial of SNG001 in hospitalised COVID-19 patients. News release. July 20, 2020.
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  32. Hung IF, Lung KC, Tso EY, et al. Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, Phase 2 trial. Lancet. 2020;395(10238):1695-1704. Available at:
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  44. Food and Drug Administration. SYLVANT (siltuximab) Prescribing Information. 2019. Available at: Accessed: April 8, 2020.
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  46. Food and Drug Administration. ACTEMRA (tocilizumab) Prescribing Information. 2019. Available at:,125472s040lbl.pdf. Accessed: April 8, 2020.
  47. Roche. Roche provides an update on the phase III COVACTA trial of Actemra/RoActemra in hospitalised patients with severe COVID-19 associated pneumonia. 2020; Accessed August 10, 2020.
  48. Sciascia S, Apra F, Baffa A, et al. Pilot prospective open, single-arm multicentre study on off-label use of tocilizumab in patients with severe COVID-19. Clin Exp Rheumatol. 2020;38(3):529-532. Available at:
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  50. Morena V, Milazzo L, Oreni L, et al. Off-label use of tocilizumab for the treatment of SARS-CoV-2 pneumonia in Milan, Italy. Eur J Intern Med. 2020;76:36-42. Available at:
  51. Capra R, De Rossi N, Mattioli F, et al. Impact of low dose tocilizumab on mortality rate in patients with COVID-19 related pneumonia. Eur J Intern Med. 2020;76:31-35. Available at:
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  57. Treon SP, Castillo JJ, Skarbnik AP, et al. The BTK inhibitor ibrutinib may protect against pulmonary injury in COVID-19-infected patients. Blood. 2020;135(21):1912-1915. Available at:
  58. Food and Drug Administration. Zanubrutinib (BRUKINSA) [Package insert]. 2019. Available at: Accessed: May 20, 2020.
  59. Food and Drug Administration. Baricitinib (OLUMIANT) [Package Insert]. 2019. Available at: Accessed: April 8, 2020.
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  62. Food and Drug Administration. Ruxolitinib (JAKAFI) [Package Insert]. 2019. Available at:
  63. Richardson P, Griffin I, Tucker C, et al. Baricitinib as potential treatment for 2019-nCoV acute respiratory disease. Lancet. 2020;395(10223):e30-e31. Available at:
  64. Stebbing J, Phelan A, Griffin I, et al. COVID-19: combining antiviral and anti-inflammatory treatments. Lancet Infect Dis. 2020;20(4):400-402. Available at:
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